Research data supporting "Heparin and heparin proteoglycan-mimetics activate platelets via PEAR1 and PI3Kbeta"

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Kardeby, Caroline and Evans, Alice and Campos, Joana and Smith, Christopher W. and Slater, Alexandre and Al-Wahaibi, Afraa M. and Martin, Eleyna M. and Severin, Sonia and Brill, Alexander and Pejler, Gunnar and Sun, Yi and Watson, Steve P. (2022) Research data supporting "Heparin and heparin proteoglycan-mimetics activate platelets via PEAR1 and PI3Kbeta".

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Dataset Details

Data creator(s):	Creators Email ORCID Kardeby, Caroline C.K.Kardeby@bham.ac.uk orcid.org/0000-0002-5025-9454 Evans, Alice UNSPECIFIED orcid.org/0000-0003-3109-4620 Campos, Joana J.Campos@bham.ac.uk orcid.org/0000-0001-8119-7607 Smith, Christopher W. c.smith.14@bham.ac.uk UNSPECIFIED Slater, Alexandre a.slater@bham.ac.uk orcid.org/0000-0001-7166-438X Al-Wahaibi, Afraa M. UNSPECIFIED orcid.org/0000-0002-0178-3356 Martin, Eleyna M. E.Martin.2@bham.ac.uk orcid.org/0000-0002-9799-4464 Severin, Sonia sonia.severin@inserm.fr orcid.org/0000-0002-1566-2619 Brill, Alexander A.Brill@bham.ac.uk orcid.org/0000-0002-4558-0390 Pejler, Gunnar gunnar.pejler@imbim.uu.se UNSPECIFIED Sun, Yi y.sun.3@bham.ac.uk orcid.org/0000-0003-0516-9000 Watson, Steve P. S.P.Watson@bham.ac.uk orcid.org/0000-0002-7846-7423
Research Data Type:	Dataset
DOI:	https://doi.org/10.25500/edata.bham.00000758
Publisher:	University of Birmingham
Funder:	European Commission
Keywords:	Heparin, protoeglycan, glycosaminoglycan, fucoidan, platelet, aggregation, sulfation, thrombus
Managing organisational unit:	Colleges (2008 onwards) > College of Medical & Dental Sciences
UoB School, Department or Institute:	Institute of Cardiovascular Sciences
Date:	7 November 2022

Additional Details

Additional Details

Project/Grant:	Horizon 2020-Project PAELLA/Grant No 893262
Primary language:	English
Collection period:	From To 1 July 2019 19 December 2021
Depositing User:	Caroline Kardeby
Date Deposited:	07 Nov 2022 13:50
Last Modified:	07 Nov 2022 14:29

Available Files

Data

Figure 1 Platel ... ifications.xlsx Figure 1 Platel ... ifications.xlsx Figure 1 Platel ... ifications.xlsx Access option: Open File: Figure 1 Platelet aggregation traces and quantifications.xlsx Content type: Data Metadata Revision: 7 Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet Licence: File size: 1MB File checksum: 91830d59cc7bb8a94174ef88ee462eb2

Figure 2 Nanobo ... cipitation.xlsx Figure 2 Nanobo ... cipitation.xlsx Figure 2 Nanobo ... cipitation.xlsx Access option: Open File: Figure 2 Nanobody inhibition and PEAR1 immunoprecipitation.xlsx Content type: Data Metadata Revision: 9 Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet Licence: File size: 90kB File checksum: cd3b5ff1ee0825658adb7753f17da452

Figure 3 The ef ... ggregation.xlsx Figure 3 The ef ... ggregation.xlsx Figure 3 The ef ... ggregation.xlsx Access option: Open File: Figure 3 The effect of desulfation on heparin-induced platelet aggregation.xlsx Content type: Data Metadata Revision: 9 Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet Licence: File size: 324kB File checksum: d4e470b0cf0f203c2e4c5b1013f6dab9

Figure 4 Inhibi ... ggregation.xlsx Figure 4 Inhibi ... ggregation.xlsx Figure 4 Inhibi ... ggregation.xlsx Access option: Open File: Figure 4 Inhibition of platelet aggregation.xlsx Content type: Data Metadata Revision: 10 Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet Licence: File size: 124kB File checksum: 13106718f52da5a9401502ad159629f9

Figure 5 and 6 ... horylation.xlsx Figure 5 and 6 ... horylation.xlsx Figure 5 and 6 ... horylation.xlsx Access option: Open File: Figure 5 and 6 PI3K inhibition of platelet aggregation and phosphorylation.xlsx Content type: Data Metadata Revision: 11 Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet Licence: File size: 223kB File checksum: 215495b0f2e3200bbbaa766a4339c53e

Figure 7 PEAR1 ... and mouse.xlsx Figure 7 PEAR1 ... and mouse.xlsx Figure 7 PEAR1 ... and mouse.xlsx Access option: Open File: Figure 7 PEAR1 immunoprecipitation human and mouse.xlsx Content type: Data Metadata Revision: 12 Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet Licence: File size: 15kB File checksum: 1455216ca458077ec756dd2501b6c393

Supplementary Figures 1-6.xlsx Supplementary Figures 1-6.xlsx Supplementary Figures 1-6.xlsx Access option: Open File: Supplementary Figures 1-6.xlsx Content type: Data Metadata Revision: 12 Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet Licence: File size: 329kB File checksum: b0d1ffa19b8a9531238bd2fde07d2c7e

Read me

Readme-CK-2022-11-07.docx Readme-CK-2022-11-07.docx Readme-CK-2022-11-07.docx Access option: Open File: Readme-CK-2022-11-07.docx Content type: ["content_typename_readme" not defined] Metadata Revision: 4 Mime-Type: application/vnd.openxmlformats-officedocument.wordprocessingml.document Licence: File size: 14kB File checksum: 3cf235933b46f397c08e94f6d4221b95

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