This study contains pain data from patients with knee osteoarthritis, including questionnaires (EQ5D, OKS, VAS), synovitis scores, and transcriptomic data of synovial tissues from patient-reported sites of pain and no pain using bulk and single-cell RNAseq. The data have been originally deposited in NCBI's Gene Expression Omnibus and are accessible through GEO Series accession number GSE176223 and GSE176308.